Biotransformations with Rhizopus arrhizus: Preparation of the enantiomers of 1-phenylethanol and 1-( fo-, m-and p-methoxyphenyl) ethanols
Publication Type:Journal Article
Source:Tetrahedron: Asymmetry, Elsevier, Volume 6, Number 9, p.2287–2290 (1995)
The fungus Rhizopus arrhizus has been used for the reduction of acetophenone and its o-, m- and p-methoxy derivatives 1a–d to the corresponding (S)-(−)-alcohols. Their racemic acetates were also hydrolyzed to (R)-(+)-alcohols. The analysis of products revealed that maximum enantioselectivity (78–88 %ee) could be obtained using m-methoxy acetophenone as substrate.