The fungus Rhizopus arrhizus has been used for the reduction of acetophenone and its o-, m- and p-methoxy derivatives 1a–d to the corresponding (S)-(−)-alcohols. Their racemic acetates were also hydrolyzed to (R)-(+)-alcohols. The analysis of products revealed that maximum enantioselectivity (78–88 %ee) could be obtained using m-methoxy acetophenone as substrate.
N. A. Salvi, Patil, P. N., Udupa, S. R., and Banerji, A., “Biotransformations with Rhizopus arrhizus: Preparation of the enantiomers of 1-phenylethanol and 1-( fo-, m-and p-methoxyphenyl) ethanols”, Tetrahedron: Asymmetry, vol. 6, pp. 2287–2290, 1995.