Publication Type:

Journal Article

Source:

Journal of Biomedical Nanotechnology, American Scientific Publishers, Volume 12, Number 1, p.43-55 (2016)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84960087082&partnerID=40&md5=fab5458fede7d6dc2c2cec43dfb43dbb

Keywords:

Breast cancer cells, Breast cancer models, Breast cancer treatment, breast tumor, Cell death, Cells, chitin, chitosan, curcumin, Diseases, Iron oxide nanoparticle, Lower critical solution temperature, Medical imaging, Nanoparticles, tumor localization, Tumors

Abstract:

Non-invasive radiofrequency (RF) frequency may be utilized as an energy source to activate thermo-responsive nanoparticles for the controlled local delivery of drugs to cancer cells. Herein, we demonstrate that 180 ±20 nm sized curcumin encapsulated chitosan-grraft-poly(/V-vinyl caprolactam) nanoparticles containing iron oxide nanoparticles (Fe3O4-CRC-TRC-NPs) were selectively internalized in cancer cells in vivo. Using an RF treatment at 80 watts for 2 min, Fe3O4-CRC-TRC-NPs, dissipated heat energy of 42 °C, which is the lower critical solution temperature (LCST) of the chitosan-grraft-poly(/V-vinyl caprolactam), causing controlled curcumin release and apoptosis to cultured 4T1 breast cancer cells. Further, the tumor localization studies on orthotopic breast cancer model revealed that Fe3O4-CRC-TRC-NPs selectively accumulated at the primary tumor as confirmed by in vivo live imaging followed by ex vivo tissue imaging and HPLC studies. These initial results strongly support the development of RF assisted drug delivery from nanoparticles for improved tumor targeting for breast cancer treatment. Copyright © 2016 American Scientific Publishers All rights reserved.

Notes:

cited By 0

Cite this Research Publication

N. Sa Rejinold, Thomas, R. Gb, Muthiah, Mc, Lee, H. Jc, Jeong, Y. Yb, Park, I. - Kc, and Jayakumar, Ra, “Breast tumor targetable Fe3O4 embedded thermo-responsive nanoparticles for radiofrequency assisted drug delivery”, Journal of Biomedical Nanotechnology, vol. 12, pp. 43-55, 2016.

207
PROGRAMS
OFFERED
5
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
9th
RANK(INDIA):
NIRF 2017
150+
INTERNATIONAL
PARTNERS
  • Amrita on Social Media

  • Contact us

    Amrita Vishwa Vidyapeetham
    Amritanagar, Coimbatore - 641 112
    Tamilnadu, India