Breast tumor targetable Fe3O4 embedded thermo-responsive nanoparticles for radiofrequency assisted drug delivery
Publication Type:Journal Article
Source:Journal of Biomedical Nanotechnology, American Scientific Publishers, Volume 12, Number 1, p.43-55 (2016)
Keywords:Breast cancer cells, Breast cancer models, Breast cancer treatment, breast tumor, Cell death, Cells, chitin, chitosan, curcumin, Diseases, Iron oxide nanoparticle, Lower critical solution temperature, Medical imaging, Nanoparticles, tumor localization, Tumors
Non-invasive radiofrequency (RF) frequency may be utilized as an energy source to activate thermo-responsive nanoparticles for the controlled local delivery of drugs to cancer cells. Herein, we demonstrate that 180 ±20 nm sized curcumin encapsulated chitosan-grraft-poly(/V-vinyl caprolactam) nanoparticles containing iron oxide nanoparticles (Fe3O4-CRC-TRC-NPs) were selectively internalized in cancer cells in vivo. Using an RF treatment at 80 watts for 2 min, Fe3O4-CRC-TRC-NPs, dissipated heat energy of 42 °C, which is the lower critical solution temperature (LCST) of the chitosan-grraft-poly(/V-vinyl caprolactam), causing controlled curcumin release and apoptosis to cultured 4T1 breast cancer cells. Further, the tumor localization studies on orthotopic breast cancer model revealed that Fe3O4-CRC-TRC-NPs selectively accumulated at the primary tumor as confirmed by in vivo live imaging followed by ex vivo tissue imaging and HPLC studies. These initial results strongly support the development of RF assisted drug delivery from nanoparticles for improved tumor targeting for breast cancer treatment. Copyright © 2016 American Scientific Publishers All rights reserved.
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