Can serum glutathione-s-transferase levels in carcinoma cervix be a predictor of radiation response?
Publication Type:Journal Article
Source:Indian Journal of Clinical Biochemistry, Volume 20, Number 1, p.95-97 (2005)
Keywords:antioxidant, article, cancer radiotherapy, clinical article, controlled study, female, follow up, free radical, glutathione transferase, human, pilot study, prediction, Prognosis, radiation exposure, relapse, serum, tumor regression, uterine cervix carcinoma
We conducted a pilot study wherein serum Glutathione-S-transferase levels were measured before and after radiotherapy in carcinoma cervix patients and correlated with response to treatment during a two-year follow-up period. Out of 17 patients who received radiotherapy, 9 showed a significant decrease (p< 0.005) while 8 showed significant increase (p< 0.004) in post radiotherapy glutathione-S-transferase values as compared to pre treatment values respectively. These patients were followed up for two years and we observed that 71% who had significant increase in post radiotherapy values had relapse of cancer within 2 years where as 66% of those who had significant decrease in post radiotherapy values had no evidence of relapse. This shows that alterations in serum Glutathione-S-transferase levels may help us to predict radiation response.
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