Cardiac fatty acid metabolism and ischemic memory imaging with nuclear medicine techniques
Publication Type:Journal Article
Source:Nuclear Medicine Communications, Volume 32, Number 8, p.672-677 (2011)
Keywords:14 (4 iodophenyl)beta methyltetradecanoic acid, 15 (3 iodophenyl)pentadecanoic acid, 15 (4 iodophenyl) 3, 15 (4 iodophenyl) 3 methylpentadecanoic acid, 15 (4 iodophenyl) 6 tellura pentadecanoic acid, 15 (4 iodophenyl)pentadecanoic acid, 16 iodopalmitic acid, 17 iodo 9 tellura heptadecanoic acid, 17 iodoheptadecanoic acid, 3 10 [13 (4' iodophenyl)] 3 (4 phenylene)tridecanoic acid, 3 dimethylpentadecanoic acid, 4 methylene heptadecanoic acid f 18, 9 methylpentadecanoic acid, acute coronary syndrome, acute heart infarction, adenosine triphosphate, Animals, beta methyl heptadecanoic acid c 11, cardiac imaging, congestive cardiomyopathy, coronary artery disease, diagnostic imaging, drug clearance, fatty acid, fatty acid metabolism, Fatty Acids, fluoro 3, fluoro 4 thia palmitate f 18, fluoro 6 thia heptadecanoic acid f 18, heart disease, heart muscle ischemia, heart muscle metabolism, heptadecanoic acid c 11, human, Humans, Image quality, iodofiltic acid i 123, kidney failure, Myocardial Ischemia, Myocardium, nonhuman, Nuclear Medicine, palmitic acid c 11, positron emission tomography, Positron-Emission Tomography, Prognosis, radiopharmaceutical agent, review, single photon emission computer tomography, thallium 201, unclassified drug, unstable angina pectoris
There has been a dramatic improvement in the clinical management of myocardial diseases with the advent of cardiac metabolic and molecular imaging. Although both myocardial perfusion and metabolic imaging provide insight of myocardium at risk for infarction or ischemia, it is known that metabolic derangements precede perfusion abnormalities, especially after reperfusion therapy. Deranged myocyte loses its flexibility of choosing the right substrate for energy production and it switches its substrate, especially between fatty acid (FA) and glucose depending on disease condition; for example, predominance of FA metabolism is noted in diabetic heart disease, whereas glucose metabolism is enhanced in pressure overload conditions such as left ventricular hypertrophy. We thus hypothesize that with better technological advancements and different substrates, the metabolic footprint of various heart diseases can be charted out in future to help in the optimization of patient management. This review attempts to discuss the importance of radionuclide-labeled FAs in cardiac metabolic and ischemic memory imaging. © 2011 Wolters Kluwer Health | Lippincott Williams and Wilkins.
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