Publication Type:

Journal Article

Source:

Research Journal of Pharmacy and Technology, Volume 10, Issue 4, p.1174-1178 (2017)

URL:

http://www.i-scholar.in/index.php/rjpt/article/view/156109

Keywords:

Intravenous Immunoglobulin, methylprednisolone, Morvan’s syndrome, Myokymia, Neuromyotonia, Paraesthesia, Peripheral nervous system

Abstract:

Morvan’s syndrome is a rare autoimmune disorder showing peripheral nervous system hyperexcitability accompanied by autonomic and central nervous system (CNS) hyperactivity. Peripheral hyperactivity includes clinical and electrophysiological evidence of painful cramps, myokymia and neuromyotonia. Acquired neuromyotonia manifests clinically in cramps, stiffness and fasciculation. Autonomic symptoms include hyperhidrosis, fluctuations in blood pressure, tachycardia. CNS hyperactivity include insomnia, agitation, hallucination, confusion, anxiety. We present a case of 48 year old female with morvan’s syndrome with central, peripheral and autonomic hyperexcitability. Admitted with alleged history of seizure and was having memory disturbances, paraesthesia and perfused perspiration with palpitation. She tested strongly positive for CASPR2 antibodies and LHI1 antibodies. On the basis of symptoms like neuromyotonia, hyperhidrosis and insomnia with features of encephalopathy and indirect immunofluorescence the patient was diagnosed to have morvan’s syndrome. Treatment was started Inj. Methylprednisolone 1gm IV, during this treatment the patient restarted dysautonomia features then intravenous immunoglobulin (IVIG) and T. Cellcept (mycophenolate mofetil) 1mg BD was given. She was managed symptomatically over time.

Notes:

cited By 0

Cite this Research Publication

S. Sreeni, Zackariah, N. Muhammed, and Lakshmi R., “A case report: Morvan’s Syndrome”, Research Journal of Pharmacy and Technology, vol. 10, no. 4, pp. 1174-1178 , 2017.

207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS