Cell-mimetic coatings for immune spheres
Publication Type:Journal Article
Source:Colloids and Surfaces B: Biointerfaces, Elsevier, Volume 123, p.845–851 (2014)
Keywords:Biomaterials, Colloids, Lipids, macrophage, Surface coating
Extrinsically induced or engineered cells are providing new therapeutic means in emerging fields such as cell therapeutics, immunomodulation and regenerative medicine. We are demonstrating a spatial induction method using lipid coatings, which can change signal presentation strength from material surface to adherent macrophage cells, that induce early cell–cell interaction leading to organotypic morphology. For that, we have developed a cell mimetic lipid coating with a rafts size to the order of transmembrane proteins (<10 nm) with enhanced lateral elastic properties. Such surface coatings are capable of reducing adherent macrophage spreading, while enabling early induction of cell–cell interaction to form organotypic macrophage colonies or “spheres” (M-spheres).
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