In the field of tissue engineering and regenerative medicine, a scaffold is an essential component that provides structural and functional support for tissue formation and regeneration. In addition, scaffolds also serve as efficient carriers and delivery vehicles for innumerable drug delivery applications. A wide range of polymers are being explored to engineer scaffolds as carriers for drugs. Based on the clinical requirement, the scaffold's properties can be tuned for site-specific delivery, sustained or controlled release, reduced concentration and dosing frequency, improved efficiency, and minimal side effects. Research is also being focused on the combinative approach of drug delivery and tissue engineering, which may offer a higher therapeutic effect from a clinical perspective. In order to achieve a therapeutic effect, the release of drug from the scaffold or carrier is crucial. Stimuli-responsive drug delivery systems can be modulated as per the therapeutic need at the site of action, thereby offering advantages over conventional systems. This chapter provides an insight into stimuli-responsive drug delivery under the influence of physiochemical properties, electrical stimulation, and magnetic stimulation.
Sowmya Srinivasan, “Nanohybrid scaffold structures for smart drug delivery applications”, in Biomimetic Nanoengineered Materials for Advanced Drug Delivery, A. Rajan Unnithan, Sasikala, A. Ramachandr, Park, C. Hee, and Kim, C. Sang, Eds. Elsevier, 2019, pp. 53 - 59.