Publication Type:

Journal Article

Source:

Progress in Polymer Science, Elsevier Ltd, Volume 39, Number 9, p.1644-1667 (2014)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906270784&partnerID=40&md5=3f21d1f62af285dacac3805b6eef74f6

Keywords:

Anti-cancer drug delivery, biocompatibility, Biodegradable polymers, biodegradation, Biomedical applications, chitin, chitosan, Diverse applications, Drug delivery, Drug/growth factor delivery, Growth factor delivery, Mechanical properties, Medical applications, Regenerative medicine, Scaffolds (biology), Structural architecture, Tissue, tissue engineering, Wound healing

Abstract:

Chitin (CT), the well-known natural biopolymer and chitosan (CS) (bio-based or "artificial polymer") are non-toxic, biodegradable and biocompatible in nature. The advantages of these biomaterials are such that, they can be easily processed into different forms such as membranes, sponges, gels, scaffolds, microparticles, nanoparticles and nanofibers for a variety of biomedical applications such as drug delivery, gene therapy, tissue engineering and wound healing. Present review focuses on the diverse applications of CT and CS membranes and scaffolds for drug delivery, tissue engineering and targeted regenerative medicine. The chitinous scaffolds of marine sponges' origin are discussed here for the first time. These CT based scaffolds obtained from Porifera possess remarkable and unique properties such as hydration, interconnected channels and diverse structural architecture. This review will provide a brief overview of CT and CS membranes and scaffolds toward different kinds of delivery applications such as anticancer drug delivery, osteogenic drug delivery, and growth factor delivery, because of their inimitable release behavior, degradation profile, mucoadhesive nature, etc. The review also provides an overview of the key features of CT and CS membranes and scaffolds such as their biodegradability, cytocompatibility and mechanical properties toward applications in tissue engineering and wound healing.

Notes:

cited By 79

Cite this Research Publication

A. Anitha, Sowmya, S., Kumar, P. T. S., Deepthi, S., Chennazhi, K. P., Ehrlich, H., Tsurkan, M., and Jayakumar, R., “Chitin and chitosan in selected biomedical applications”, Progress in Polymer Science, vol. 39, pp. 1644-1667, 2014.

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