Publication Type:

Journal Article

Source:

International Journal of Biological Macromolecules, Volume 44, Number 4, p.320-325 (2009)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-62949238907&partnerID=40&md5=9726b1514d986e1260282186e749b5d9

Keywords:

Animals, article, beta cyclodextrin, beta-Cyclodextrins, biodegradability, Carbodiimides, Cell Line, cell strain L 929, chitosan, controlled drug release, cross linking, cytotoxicity, Drug Delivery Systems, drug solubility, fibroblast, Fibroblasts, Fourier Transform Infrared, freeze drying, glutaraldehyde, healing, human, human cell, Hydrogen-Ion Concentration, hydrophobicity, ketoprofen, Magnetic Resonance Spectroscopy, Morphology, nitroblue tetrazolium test, Pharmaceutical Preparations, Spectroscopy, swelling, temperature, tissue engineering, Tissue regeneration, Tissue Scaffolds, Water

Abstract:

Biodegradable scaffolds composed of chitosan-g-β-cyclodextrin (chit-g-β-CD) were prepared by freeze-drying method as synthetic extracellular matrices to fill the gap during the healing process. Due to the presence of β-CD, these scaffolds can be used as a matrix for drug loading and controlled release. The morphology, swelling and drug release properties of the scaffolds were found to be dependent on the extent of cross-linking density in the scaffolds. The drug dissolution profile showed that chit-g-β-CD scaffolds provided a slower release of the entrapped ketoprofen than chitosan scaffold. The MTT assay showed that there is no obvious cytotoxicity of chit-g-β-CD scaffolds cross-linked with 0.01 M of glutaraldehyde against the fibroblasts (L929) cells. These results suggest that chit-g-β-CD scaffolds may become a potential biodegradable active filling material with controlled drug release capability, which provide a healthy environment and enhance the surrounding tissue regeneration. © 2009 Elsevier B.V. All rights reserved.

Notes:

cited By (since 1996)28

Cite this Research Publication

Ma Prabaharan and Jayakumar, Rb, “Chitosan-graft-β-cyclodextrin scaffolds with controlled drug release capability for tissue engineering applications”, International Journal of Biological Macromolecules, vol. 44, pp. 320-325, 2009.