Coleus plectranthus, an herbal extract is an excellent wound healing agent for both acute and chronic wounds. Its anti-inflammatory property would be helpful to prevent scar formation. In this work, we developed coleus plectranthus herb extract incorporated chitosan sponge for wound healing applications. The morphology analysis of the prepared sponges was done by SEM analysis. The herb incorporated chitosan sponge showed high swelling ability in comparison to the conventional sponge. The protein adsorption ability of the prepared sponge was evaluated and the data proved the enhanced protein adsorption capability of the sponges. The sponges showed excellent antibacterial activity against Staphylococcus aureus, Klebsiella sp. and Acinetobacter sp. The cytocompatibility of the herb incorporated sponge was studied by cell cycle analysis and cell viability assay. These results showed that the sponges were cytocompatible and promote cellular growth.
L. R. Lakshman, Kumar, P. T., Nair, S. V., Nair, S. V., and Jayakumar, R., “Chitosan sponge containing the herb coleus plectranthus as a wound dressing”, Journal of Chitin and Chitosan Science, vol. 1, pp. 13–20, 2013.