Wistar rats 15 days old were given intraperitoneally allitin (diallyl disulphide 98 and diallyl trisulphide 2%, obtained from garlic (Allium sativum) oil) 100 mg/kg bodyweight. Plasma cholesterol decreased significantly within 30 min and liver cholesterol within 4 h. Total lipids in plasma decreased after 30 min and increased in liver but total lipids in microsomes of liver decreased. Lipid peroxidation in liver homogenates decreased gradually. Smaller amounts of allitin had different effects on total lipids and cholesterol in plasma and liver.
C. K. Pushpendran, Devasagayam, T. P. A., Banerji, A., and Eapen, J., “Cholesterol-lowering effect of allitin in suckling rats.”, Indian journal of experimental biology, vol. 18, pp. 858–861, 1980.