Publication Type:

Journal Article


Pancreas, Volume 39, Number 1, p.e11-e16 (2010)



adult, Alcoholic, alcoholic pancreatitis, amino acid blood level, article, Biological, biotransformation, Chronic, chronic pancreatitis, comparative study, controlled study, creatinine, creatinine blood level, creatinine urine level, cyanocobalamin, cysteine, diabetic patient, dietary intake, disease association, erythrocyte, Erythrocytes, female, folic acid, folic acid blood level, glutathione, homocysteine, human, Humans, hyperhomocysteinemia, major clinical study, male, metabolite, methionine, methylation, middle aged, Models, multivariate analysis, multivariate logistic regression analysis, pancreas calcification, pancreas disease, pancreatitis, parameter, priority journal, Regression analysis, risk assessment, signal transduction, sulfate, Sulfates, sulfur, sulfuration, transmethylation, tropical pancreatitis, vitamin blood level, Young Adult


{Objectives: Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. Methods: We estimated homocysteine and its metabolites in 45 alcoholic CP patients, 45 tropical CP patients, and 48 healthy controls. Results: Significant increases in plasma total homocysteine and decreases in red blood cell folate, reduced glutathione, plasma methionine, cysteine, and urinary inorganic sulfate/creatinine ratio were observed in both alcoholic and tropical CP patients in comparison with healthy controls. Red blood cell glutathione and plasma cysteine levels were significantly lower in alcoholic than in tropical CP patients. However, plasma vitamin B12 levels were comparable between CP patients and controls. No significant differences in these parameters were observed between diabetic patients and nondiabetic patients. Multivariate regression analysis showed a significant negative correlation between homocysteine and folate (r = -0.415


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Cite this Research Publication

B. Na Girish, Vaidyanathan, Kb, Rao, NbAnanth, Rajesh, Gc, Reshmi, Sd, and Balakrishnan, Vc, “Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways”, Pancreas, vol. 39, pp. e11-e16, 2010.