Publication Type:

Journal Article


Otolaryngology - Head and Neck Surgery, Volume 139, Number 5, p.702-707 (2008)



Adjuvant, adult, advanced cancer, aged, Antineoplastic Agents, article, cancer chemotherapy, cancer radiotherapy, Carcinoma, Chemotherapy, clinical article, controlled study, Cross-Sectional Studies, disease free interval, female, Follow-Up Studies, functional assessment, human, Humans, Karnofsky Performance Status, Laryngeal Neoplasms, laryngectomy, larynx cancer, male, middle aged, Neoplasm Staging, outcome assessment, quality of life, questionnaire, Radiotherapy, treatment outcome, xerostomia


Objective: To compare quality of life (QOL) of patients with advanced laryngeal cancers treated by total laryngectomy with those who received concurrent chemoradiotherapy. Study Design: This is a cross-sectional study of the patients treated in our institution who have completed one year of follow-up and were disease-free at the time of evaluation. Subjects and Method: Forty patients treated for advanced cancer of the larynx (stage III/IV), either by concurrent chemoradiation (11) or total laryngectomy and postoperative radiation (29), have been included in this study. The Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) version 4 questionnaire was used. Results: Total scores for overall QOL are equal in both treatment groups (P = 0.69). Scores for individual components are similar in both treatment groups. However, dryness of mouth is significantly worse in the chemoradiotherapy group (P = 0.01) and ability to communicate with others is poorer in the laryngectomy group (P = 0.03). Conclusion: Long-term overall QOL remains similar in all the patients treated for advanced carcinoma of the larynx irrespective of treatment modality. © 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation.


cited By (since 1996)11

Cite this Research Publication

N. P. Trivedi, Swaminathan, D. K., Thankappan, K., Chatni, S., Kuriakose, M. A., and Dr. Subramania Iyer K., “Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy”, Otolaryngology - Head and Neck Surgery, vol. 139, pp. 702-707, 2008.