Publication Type:

Journal Article

Source:

Journal of Proteomics and Bioinformatics, Volume 4, Number 9, p.184-189 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84861775201&partnerID=40&md5=89a1c37b08ac234c9e5e37c3a7039cfe

Keywords:

article, enzyme substrate complex, gene control, hydroxymethylglutaryl coenzyme A reductase kinase, insulin receptor substrate, Janus kinase, leptin, mitogen activated protein kinase, molecular dynamics, phosphatidylinositol 3 kinase, phospholipase C gamma, protein homeostasis, protein protein interaction, protein transport, Raf protein, Ras protein, signal transduction, STAT protein, transcription regulation

Abstract:

Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations. © 2011 Nanjappa V, et al.

Notes:

cited By (since 1996)7

Cite this Research Publication

Va Nanjappa, Raju, Ra, Muthusamy, Bab, Sharma, Jac, Thomas, J. Ka, Nidhina, P. A. HdHaridas, Harsha, H. Ca, Pandey, Aef g h, Anilkumar, Gd, and Prasad, T. Sab c Keshav, “A Comprehensive Curated Reaction Map of Leptin Signaling Pathway”, Journal of Proteomics and Bioinformatics, vol. 4, pp. 184-189, 2011.