A Comprehensive Curated Reaction Map of Leptin Signaling Pathway
Publication Type:Journal Article
Source:Journal of Proteomics and Bioinformatics, Volume 4, Number 9, p.184-189 (2011)
Keywords:article, enzyme substrate complex, gene control, hydroxymethylglutaryl coenzyme A reductase kinase, insulin receptor substrate, Janus kinase, leptin, mitogen activated protein kinase, molecular dynamics, phosphatidylinositol 3 kinase, phospholipase C gamma, protein homeostasis, protein protein interaction, protein transport, Raf protein, Ras protein, signal transduction, STAT protein, transcription regulation
Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations. © 2011 Nanjappa V, et al.
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