Colon cancer is the growth arising from the inner wall of colon, which is a part of large intestine. Wnt-signalling pathway has been recognized as a crucial factor in carcinogenesis. Mutations in this pathway lead to the accumulation of beta –catenin which initiates oncogenesis. Thus beta catenin is selected as the target to resist against the uncontrolled growth. In this work, a total of 10 substituted (4-aminophenyl) benzothiazole derivatives were selected for docking studies. These molecules were selected based on their potent antitumor, antifungal, antimicrobial, anthelmintic antidiabetic, and anticonvulsant, anti-inflammatory and antimalarial properties. The primary and secondary characterizations of protein(PDB ID:3SLA) were achieved from pdb structures using the aid of protparam and sopma tools.Insilico docking analysis were carried out, using Argus lab version 4.0 based on their scoring functions and Lipinski rule of 5 .It revealed that these derivatives have shown better docking score than the standard drug RALTITREXED; hence, can be used to reduce one of its side effect inflammation , and showed strong anticancer activity by the suppression of beta catenin, thus making them possible inhibitors against colon carcinogenesis. The main objective of our research work is to conclude that substituted (4-aminophenyl) benzothiazole derivatives are better drugs than RALTITREXED as it shows higher binding energy with the modeled protein. So these substituted derivatives can be used as suitable drug of choice against colon cancer.
T. James, Rajendran, A., Martin, S., Easo, R., Krishnan, N. C., Asha Asokan Manakadan, and .T.S, S., “Computational Approach on The Drug Affinity Studies of Substituted (4-Aminophenyl)Benzothiazole Derivatives Against Colon Cancer”, Research Journal of Pharmaceutical, Biological and Chemical Sciences (RJPBCS), vol. 8(2), pp. 402-407, 2017.