Publication Type:

Conference Paper

Source:

2017 International Conference on Advances in Computing, Communications and Informatics (ICACCI), IEEE, Udupi, India (2017)

URL:

https://ieeexplore.ieee.org/document/8125891/

Keywords:

apoptosis level, apoptosome expression, BAK oligomerization, biochemical systems theory, Biochemistry, bioinformatics, biological interactions, Biological system modeling, caspase 9, cellular biophysics, Computational model, computational modeling, Diseases, DNA, dopamine, dopaminergic diseased pathway, dopaminergic pathway, mathematical model, Mathematical modeling, Mathematical models, Medical computing, mitochondrial pathway model, molecular biophysics, neural cell death, Neurophysiology, oxidative stress, P53-DNA damage pathway, Parkinson disease, Parkinson's disease, PD condition, Production, Proteins, signaling pathways

Abstract:

In this study, we present a computational model of Parkinson's disease (PD) that includes different biological interactions that leads to neural cell death with the use of biochemical systems theory. The model incorporates a set of important pathways in PD including dopaminergic pathway, mitochondrial pathway and P53 - DNA damage pathway. Modeling signaling pathways and simulations were performed using biochemical systems theory. Initial concentrations have been taken from experimental data in literature and were used to model the changes. Results generated by dopaminergic diseased pathway show 45% decrease in dopamine, compared to normal condition. In addition, the activity of MOMP, Caspase 9 and Apoptosome expression in diseased condition within mitochondrial pathway model have been observed in the results. The expression levels of BAX and MOMP were reconstructed and simulations suggest oligomerization of BAK leads to the elevation of MOMP. An increase in oxidative stress and apoptosis level also has been observed in the PD condition, compared to the control allowing comparisons between normal and diseased conditions with these mathematical models.

Cite this Research Publication

Hemalatha Sasidharakurup, Pyaree Dash, Asha Vijayan, Dr. Bipin G. Nair, and Dr. Shyam Diwakar, “Computational modelling of apoptosis in parkinson's disease using biochemical systems theory”, in 2017 International Conference on Advances in Computing, Communications and Informatics (ICACCI), Udupi, India, 2017.