Consequences of alcohol consumption on neurotransmitters - An overview
Publication Type:Journal Article
Source:Current Neurovascular Research, Volume 5, Number 4, p.266-272 (2008)
Keywords:4 aminobutyric acid receptor, alcohol, Alcohol abuse, alcohol consumption, Alcohol Drinking, alcohol withdrawal, Alcoholic Beverages, Alcoholism, amnesia, Animals, Brain, brain dysfunction, brain region, clinical feature, confusion, frontal lobe, GABAergic system, GABAergic transmission, glutamic acid, glycine, hippocampus, Humans, lethargy, long term exposure, medulla oblongata, nerve excitability, Neurotransmitter Agents, neurotransmitter release, nonhuman, pons, priority journal, review, serotonin, serotonin brain level, serotonin release, Synaptic Transmission
Alcohol one of the important products of the global addiction alters brain function by interacting with multiple neurotransmitter systems, thereby disrupting the delicate balance between inhibitory and excitatory neurotransmitters. Alcohol positively reinforces drinking by producing a mild euphoria. The reinforcing effects of alcohol are mediated by several neurochemical systems and are associated with some of the behavioral manifestations of intoxication. Alcohol consumption is initially accompanied by decreased attention, alterations in memory, mood changes and drowsiness. Generally all vital functions of brain depend on a delicate balance between excitatory and inhibitory neurotransmission, which in turn dependent on short, and long term alcohol consumption. Detailed understanding of alcohol's mechanism of action on the neurotransmitters of brain, it is a prerequisite in discovering effective treatments for both alcohol abuse and alcoholism. This review covers the elaborate literature on the subject, and highlights the functions and interactions of neurotransmitters and alcoholism. ©2008 Bentham Science Publishers Ltd.
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