Publication Type:

Journal Article


Biochemical Archieves, Volume 8, p.335-338 (1992)



The effect of adriamycin(ADR) chemotherapy on cratinine phosphokinase (CPK) and pathological lesions in heart was studied with Balb/c mice. WR-1065 was used as a chemoprotector against the cardiotoxicity of ADR. CPK levels were measured at different intervals and the heart of treated animals were analyzed for pathological changes. The results indicate that there is a significant relationship between the CPK levels and pathological lesions. WR-1065 could reduce tge cardiotoxicity induced by ADR, without altering its antineoplastic activity

Cite this Research Publication

Dr. Damodaran Vasudevan, “Creatine Kinase and Cardiotoxicity in Adriamycin Chemotherapy and its Modification by WR-1065”, Biochemical Archieves, vol. 8, pp. 335-338, 1992.