Publication Type:

Journal Article

Source:

Immunological Investigations, Informa Healthcare, Volume 24, Number 4, p.565-571 (1995)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0028985870&partnerID=40&md5=2cf4b8beab549e919025c7f3b60b025a

Keywords:

adult, article, Carcinoma, Cell Transformation, clinical article, controlled study, Cultured, deoxyadenosine triphosphate, Disease Progression, female, gene expression, Gene Expression Regulation, guanidine isothiocyanate, human, human cell, Immunologic Deficiency Syndromes, interleukin 2, interleukin 2 receptor, Interleukin-2, isothiocyanic acid derivative, Lymphocyte Activation, male, Messenger, messenger RNA, neoplasm, Neoplasm Proteins, Neoplastic, Non-U.S. Gov't, northern blotting, phosphorus 32, phytohemagglutinin, Phytohemagglutinins, priority journal, receptor subtype, Receptors, RNA, stomach carcinoma, Stomach Neoplasms, Support, T lymphocyte activation, T-Lymphocytes, Tumor Cells, unclassified drug

Abstract:

Peripheral blood T lymphocytes from 15 patients with gastric carcinoma and 6 normal healthy controls were evaluated for Interleukin-2 R gene expression. Total RNA was extracted from T cell-enriched fractions of patients as well as from control peripheral blood lymphocytes, with or without mitogenic stimulation. The presence of mRNA for IL-2 R alpha evaluated by Northern blot analysis revealed that unstimulated T cells expressed lower levels of IL-2 R mRNA than PHA stimulated T cells. Expression of both IL-2 R alpha transcripts (3.5 and 1.5 Kb) were either not detectable or only weakly detectable on T lymphocytes from patients even after mitogenic stimulation. In contrast, a significant rise in the expression of both IL-2 R alpha transcripts was observed on T cells from normal controls followed by mitogenic challenge. This paper reports on the defective IL-2 R alpha gene expression in gastric carcinoma patients, which may explain one of the causes of immunodeficiency associated with neoplastic transformation and progression. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Notes:

cited By 2

Cite this Research Publication

K. Suresh, Dr. Damodaran Vasudevan, and Jayavardhanan, K. K., “Defective interleukin - 2 r gene expression in gastric carcinoma patients”, Immunological Investigations, vol. 24, pp. 565-571, 1995.

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