Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases
Publication Type:Journal Article
Source:Journal of Advanced Pharmaceutical Technology and Research, Volume 3, Number 2, p.106-111 (2012)
Keywords:animal experiment, antiinfective agent, antimicrobial activity, article, Candida albicans, carbomer, controlled study, drug dosage form comparison, drug dose increase, drug formulation, drug screening, drug stability, gel, histocompatibility, in vitro study, male, mouse, nonhuman, ointment, plant extract, priority journal, Pseudomonas aeruginosa, Samadera indica, Samadera indica extract, Simaroubaceae, single drug dose, skin disease, Staphylococcus aureus, toxicity testing, unclassified drug
Samadera indica Gaetrn (Simaroubaceae) is claimed to possess various pharmacological activities like antioxidant, antifungal, antitumor, antiviral, and so on, but its taste is bitter. The aim of the present study is to investigate the toxicity of the methanolic extract and to develop suitable herbal formulations of the methanolic extract of Samadera indica, having efficient antimicrobial activity. The methanolic extract prepared from the dried leaves of Samadera indica by continuous hot percolation, were used to examine the toxicity, according to the OECD 423 guidelines, in Swiss Albino mice. Topical formulations were prepared by incorporating Samadera indica (5% w / w) in an emulsifying ointment and a carbopol gel base and evaluated for physical parameters and in-vitro antimicrobial activity (S. aureus, P. aeruginosa and C. albicans). The study reveals that no animals under the study showed any clinical signs of toxicity or mortality when administered a dose of 5 - 2000 mg / kg body weight. Therefore, the maximum tolerated dose of the methanolic extract of Samadera indica was above 2000 mg / kg body weight. The formulated ointment and gel had acceptable physical parameters that showed that they were compatible with the skin, and in addition to this, these formulations passed the short-term stability studies. The in-vitro antimicrobial activity studies showed that the formulated ointment showed significantly strong (p < 0.05) activity against S. aureus, P. aeruginosa and C. albicans than the formulated gel. Thus, the present study concludes that the formulated ointment and gel are safe and efficient antimicrobial formulations for the topical delivery of the methanolic extract of Samadera indica.
cited By (since 1996)0
Cite this Research Publication
Related Research Publications
- Development of phytovesicles containing triterpenoids from Samadera indica
- Isolation and evaluation of antimicrobial properties of isolated phytoconstituents of fruits of Helicteres isora Linn.
- Chitosan-hyaluronic acid/nano silver composite sponges for drug resistant bacteria infected diabetic wounds
- Antimicrobial drugs encapsulated in fibrin nanoparticles for treating microbial infested wounds
- Antimicrobial Drugs Encapsulated in Fibrin Nanoparticles for Treating Microbial Infested Wounds