Publication Type:

Journal Article

Source:

International Journal of Drug Development and Research, Volume 2, Number 2, p.388-393 (2010)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-78650146240&partnerID=40&md5=18de679b6dce9d143e0d279e1aedc094

Keywords:

accuracy, article, chrysophanic acid, drug dosage form, drug formulation, gel, methanol, spectrophotometry, ultraviolet radiation

Abstract:

A simple, accurate, sensitive, precise & reproducible UV spectroscopic method has been developed for the estimation of chrysophanol in pure form and in gel formulations. Chrysophanol was estimated at 225nm in methanol medium. Beer's law was obeyed in the concentration range of 1-10 μg/ml (r2=0.998). The method was tested and validated for various parameters according to the ICH(International Conference on Harmonization) guidelines. The detection and quantification limits were found to be 0.57μg/ml and1.72μg/ml, respectively. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation < 1 %), while being simple, cheap and less time consuming, and hence can be suitably applied for the estimation of chrysophanol in different dosage forms.

Notes:

cited By (since 1996)0

Cite this Research Publication

D. Ta Vasudevan, Dinesh, K. Rb, Gopalakrishnan, Sc, Ravikumar, K. Ga, Sundaram, K. Rd, and Aneesh, T. Pa, “Development and validation of spectrophotometric method for chrysophanol in gel formulations”, International Journal of Drug Development and Research, vol. 2, pp. 388-393, 2010.