Publication Type:

Journal Article


Nanoscale, Volume 3, Number 6, p.2461-2464 (2011)



animal, Animals, article, Cell Survival, Cercopithecus, Cercopithecus aethiops, chemical phenomena, chemistry, Confocal, confocal microscopy, drug effect, flow cytometry, Graphite, Hydrophobic and Hydrophilic Interactions, Materials Testing, microscopy, nanomaterial, Nanostructures, oxidative stress, toxicity testing, Toxicity Tests, Vero cell, Vero cells


We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.


cited By 84

Cite this Research Publication

A. Sasidharan, Panchakarla, L. S., Chandran, P., Menon, D., Nair, S., Rao, C. N., and Koyakutty, M., “Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene.”, Nanoscale, vol. 3, pp. 2461-2464, 2011.