Docking studies on Peperomia pellucida as antidiabetic drug
Publication Type:Journal Article
Source:International Journal of Pharmacy and Pharmaceutical Sciences, Volume 4, Number SUPPL. 4, p.375-376 (2012)
Keywords:aldehyde reductase, antidiabetic activity, antidiabetic agent, article, computer model, computer program, molecular docking, Peperomia, Peperomia pellucida, quercetin, yohimbine
Molecular docking, the technique employed for predicting and analyzing the interactions between protein receptors and ligands, is now an integral aspect in drug discovery and development area. In spite of various treatment regimens for diabetes, the third leading cause of death, there exist demand for newer molecules. Hence, the present study was aimed to screen the identified constituents of Peperomia pellucida, the traditionally used drug for diabetes, to determine the potent constituent attributing antidiabetic activity using insilico approach. Docking studies on the constituents were carried out using Autodock 4.0 software against the receptor aldose reductase. Analysis of the results clearly indicated yohimbine as the potent bioactive constituent attributing antidiabetic activity and it showed significant activity than the standard, Quercetin.
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