Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery
Publication Type:Journal Article
Source:International Journal of Biological Macromolecules, Volume 62, p.35-43 (2013)
Keywords:article, biodegradation, blood compatibility, cell transport, chitin, concentration response, controlled study, differential scanning calorimetry, doxorubicin, drug cytotoxicity, drug delivery system, drug dosage form comparison, drug effect, drug formulation, drug release, fluorescence microscopy, gel, human, human cell, in vitro study, infrared spectroscopy, internalization, light scattering, particle size, pH measurement, physical chemistry, polycaprolactone, scanning electron microscopy
In this work, we developed a pH responsive chitin-poly(caprolactone) composite nanogels (chitin-PCL CNGs) system for non-small cell lung cancer (NSCLC). A hydrophilic drug, doxorubicin (Dox) was loaded in Chitin-PCL CNGs (Dox-chitin-PCL CNGs). Both control and drug loaded systems were analyzed by DLS, SEM, FTIR and TG/DTA. The size ranges of the control composite nanogels and their drug loaded counterparts were found to be 70. ±. 20 and 240. ±. 20. nm, respectively. The control chitin-PCL CNGs and Dox-chitin-PCL CNGs showed higher swelling and degradation in acidic pH. Drug entrapment efficiency and in-vitro drug release studies were carried out and showed a higher drug release at acidic pH compared to neutral pH. Cellular internalization of the nanogel systems was confirmed by fluorescent microscopy. Dox-Chitin-PCL CNGs showed dose dependent cytotoxicity toward A549 (adenocarcinomic human alveolar basal epithelial cells) cancer cells. Furthermore, the results of in-vitro hemolytic assay and coagulation assay substantiate the blood compatibility of the system. These results indicate that chitin-PCL CNGs is a novel carrier for delivery of anticancer drugs. © 2013 Elsevier B.V.
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