Publication Type:

Journal Article

Source:

Carbohydrate Polymers, Volume 87, Number 3, p.2352-2356 (2012)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-83655201237&partnerID=40&md5=ef7195de19240c53488e26062185f795

Keywords:

Cancer cells, Cell culture, Cell lines, Cells, Cellular uptake, chitin, cytotoxicity, Diseases, doxorubicin, Drug delivery, FTIR, In-vitro, Liver cancers, MTT assays, Nanogels, Nanostructured materials, PH-responsive, Responsivity, swelling

Abstract:

This work deals with preparation of doxorubicin loaded chitin nanogels and were characterized by SEM, DLS and FTIR for cancer drug delivery. The in vitro cytotoxicity studies of 130-160 nm sized doxorubicin loaded chitin nanogels were studied using MTT assay on L929, PC3, MCF-7, A549 and HEPG2 confirmed that relatively higher toxicity on cancer cells comparing to normal L929 cells. The internalization studies showed a significant uptake of doxorubicin loaded chitin nanogels in all the tested cell lines. All the above results indicated that doxorubicin loaded chitin nanogels can be used for prostate, breast, lung and liver cancer. © 2011 Elsevier Ltd. All rights reserved.

Notes:

cited By 23

Cite this Research Publication

Dr. Jayakumar Rangasamy, Nair, A., Rejinold, N. S., Maya, S., and Nair, S. V., “Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells”, Carbohydrate Polymers, vol. 87, pp. 2352-2356, 2012.

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