Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells
Publication Type:Journal Article
Source:Carbohydrate Polymers, Volume 87, Number 3, p.2352-2356 (2012)
Keywords:Cancer cells, Cell culture, Cell lines, Cells, Cellular uptake, chitin, cytotoxicity, Diseases, doxorubicin, Drug delivery, FTIR, In-vitro, Liver cancers, MTT assays, Nanogels, Nanostructured materials, PH-responsive, Responsivity, swelling
This work deals with preparation of doxorubicin loaded chitin nanogels and were characterized by SEM, DLS and FTIR for cancer drug delivery. The in vitro cytotoxicity studies of 130-160 nm sized doxorubicin loaded chitin nanogels were studied using MTT assay on L929, PC3, MCF-7, A549 and HEPG2 confirmed that relatively higher toxicity on cancer cells comparing to normal L929 cells. The internalization studies showed a significant uptake of doxorubicin loaded chitin nanogels in all the tested cell lines. All the above results indicated that doxorubicin loaded chitin nanogels can be used for prostate, breast, lung and liver cancer. © 2011 Elsevier Ltd. All rights reserved.
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