Objective: The aim was to evaluate the drug utilization pattern of anti-diabetic drugs in diabetic outpatients and monitor the adverse drug reactions (ADRs) associated with anti-diabetic therapy. Methods: A prospective observational study was carried out in adult diabetic patients visiting the outpatient Departments of General Medicine and Endocrinology of a tertiary care hospital. Demographic data, drug utilization pattern and ADRs due to anti-diabetic drugs were summarized. Results: In the present study, 99 (50.3%) of the 197 diabetic patients were males. Majority of patients were in the age group of 51-60 years (39.6%) and most of the patients (36.5%) had a diabetic history of <5 years. Metformin was the most commonly prescribed drug (68%), followed by sulfonylurea class of drugs (49.7%). Nearly, 42% patients were using insulin preparations with 30.4% using biphasic isophane human insulin. Majority of the patients (58.4%) were on multidrug therapy with two drug therapies being received by nearly 40%. Metformin was the most commonly prescribed drug in monotherapy (18.8%) and glimepiride + metformin was the most common two drug therapy (13.2%). Co-morbid condition was found in 172 patients (87.3%) with hypertension (68.5%) being the most common co-morbid condition. 17 ADRs were observed with hypoglycemia being the most common ADR reported. Conclusions: Metformin was the most commonly used drug. The prescribing trend also appears to be moving towards combination therapy particularly two drug therapies. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.
S. M. Alex, Sreelekshmi, B., Smitha, S., Jiji, K., Menon, A. S., and Dr. Umadevi P., “Drug utilization pattern of anti-diabetic drugs among diabetic outpatients in a tertiary care hospital”, Asian Journal of Pharmaceutical and Clinical Research, vol. 8, pp. 144-146, 2015.