Publication Type:

Journal Article

Source:

Indian Pediatr, Volume 55, Issue 5, p.400-404 (2018)

URL:

https://www.ncbi.nlm.nih.gov/pubmed/29845954

Keywords:

Cardiac Surgical Procedures, Cross-Sectional Studies, Developmental Disabilities, female, Heart Defects, Congenital, Humans, India, infant, male, Neurodevelopmental Disorders, Postoperative Complications, Prospective Studies, Risk Factors

Abstract:

<p><b>OBJECTIVE: </b>To assess neurodevelopmental status in Indian infants undergoing corrective surgery for congenital heart disease (CHD) and to analyze factors associated with neurodevelopmental delay.</p><p><b>DESIGN: </b>Cross-sectional study.</p><p><b>SETTING: </b>Tertiary-care pediatric cardiology facility.</p><p><b>PARTICIPANTS: </b>Consecutive infants undergoing corrective surgery for CHD (January 2013 -December 2014). Palliative procedures, and patients with known genetic syndromes were excluded.</p><p><b>MAIN OUTCOME MEASURES: </b>Neurodevelopmental evaluation 3 months, and one year after surgery using Developmental Assessment Scales for Indian Infants (DASII); scores were categorized as delayed if ≤70.</p><p><b>RESULTS: </b>Of the 162 children enrolled, delayed PDI and MDI scores were observed in 33.5% and 19.6% of patients at 3 months, respectively; this reduced to 14.5%on 1-year follow-up. On multivariate analysis, delayed PDI outcome at one year was predicted by early term birth and one-year postoperative head circumference Z-score <-2. Delayed MDI was associated with higher mean perfusion pressure on cardiopulmonary bypass. Cardiac diagnosis and peri-operative factors did not impact neurodevelopmental outcomes.</p><p><b>CONCLUSIONS: </b>Neurodevelopmental status is delayed in 14.5% of infants one year after corrective infant heart surgery.</p>

Cite this Research Publication

R. Sharon Solomon, Sasi, T., Sudhakar, A., Kumar, R. Krishna, and Vaidyanathan, B., “Early Neurodevelopmental Outcomes After Corrective Cardiac Surgery In Infants.”, Indian Pediatr, vol. 55, 5 vol., no. 5, pp. 400-404, 2018.

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