Echocardiographic screening for rheumatic heart disease in high and low risk Australian children
Publication Type:Journal Article
Source:Circulation, Lippincott Williams and Wilkins, Volume 129, Number 19, p.1953-1961 (2014)
Keywords:adolescent, article, Australia, bicuspid aortic valve, borderline state, cardiologist, cardiovascular risk, child, Cohort Studies, confidence interval, controlled study, demography, echocardiography, female, heart atrium septum defect, heart ventricle septum defect, high risk patient, human, Humans, Indigenous Australian, longitudinal study, low risk population, major clinical study, male, Mass Screening, mitral valve prolapse, Observer Variation, patent ductus arteriosus, Pediatrics, Population Groups, Preschool, prevalence, priority journal, Retrospective Studies, rheumatic heart disease, Risk Factors, sex ratio, Torres Strait Islander
Background: Echocardiographic screening for rheumatic heart disease (RHD) is becoming more widespread, but screening studies to date have used different echocardiographic definitions. The World Heart Federation has recently published new criteria for the echocardiographic diagnosis of RHD. We aimed to establish the prevalence of RHD in high-risk Indigenous Australian children using these criteria and to compare the findings with a group of Australian children at low risk for RHD. Methods and Results: Portable echocardiography was performed on high-risk Indigenous children aged 5 to15 years living in remote communities of northern Australia. A comparison group of low-risk, non-Indigenous children living in urban centers was also screened. Echocardiograms were reported in a standardized, blinded fashion. Of 3946 high-risk children, 34 met World Heart Federation criteria for definite RHD (prevalence, 8.6 per 1000 [95% confidence interval, 6.0-12.0]) and 66 for borderline RHD (prevalence, 16.7 per 1000 [95% confidence interval, 13.0-21.2]). Of 1053 low-risk children, none met the criteria for definite RHD, and 5 met the criteria for borderline RHD. High-risk children were more likely to have definite or borderline RHD than low-risk children (adjusted odds ratio, 5.7 [95% confidence interval, 2.3-14.1]; P<0.001). Conclusions: The prevalence of definite RHD in high-risk Indigenous Australian children approximates what we expected in our population, and no definite RHD was identified in the low-risk group. This study suggests that definite RHD, as defined by the World Heart Federation criteria, is likely to represent true disease. Borderline RHD was identified in children at both low and high risk, highlighting the need for longitudinal studies to evaluate the clinical significance of this finding. © 2014 American Heart Association, Inc.
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