Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated wistar rats

Publication Type:

Journal Article

Authors:

Vasudevan, D.M; Mailankot, M.; Jayalekshmi, H; Chakrabarti, A; Alang, N

Source:

Indian Journal of Experimental Biology, Volume 47, Number 7, p.608-610 (2009)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-70349459644&partnerID=40&md5=cb0c218fa464c644426b1cc870e0aa4b

Keywords:

adenosine triphosphatase (potassium sodium), alcohol, Alcoholism, alpha tocopherol, alpha-Tocopherol, animal, Animals, antioxidant, Antioxidants, article, drug antagonism, drug effect, Ethanol, kidney, lipid peroxidation, male, metabolism, oxidative stress, rat, Rats, Rattus norvegicus, Sodium-Potassium-Exchanging ATPase, Wistar, Wistar rat

Abstract:

Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid

Notes:

cited By 3

Cite this Research Publication

D. M. Vasudevan, Mailankot, M., Jayalekshmi, H., Chakrabarti, A., and Alang, N., “Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated wistar rats”, Indian Journal of Experimental Biology, vol. 47, pp. 608-610, 2009.

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