Publication Type:

Journal Article

Source:

Indian Journal of Experimental Biology, Volume 45, Number 8, p.683-688 (2007)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-35148891123&partnerID=40&md5=e500a6c9544c3d03570eb7fbbec5e9e5

Keywords:

alanine aminotransferase, Alanine Transaminase, alcohol, alcohol liver disease, Alcoholic, alpha tocopherol, alpha-Tocopherol, alpha-tocopherol acetate, animal, Animals, article, Bagg albino mouse, cytokine, Cytokines, drug antagonism, drug derivative, drug effect, Ethanol, glutathione, helper cell, Helper-Inducer, hepatitis, immunology, Inbred BALB C, male, metabolism, Mice, mouse, Mus, oxidative stress, phosphatidylcholine, Phosphatidylcholines, superoxide dismutase, T-Lymphocytes, thiobarbituric acid reactive substance, Thiobarbituric Acid Reactive Substances, unclassified drug, vitamin B complex

Abstract:

<p>The alcoholic liver disease usually causes overall immunological alterations which might be attributed to hepatic disease, to ethanol action, and/or to malnourishment. In the present study, efficacy of lecithin with vitamin-B complex to treat ethanol induced immunomodulatory activity was compared with the effect of lecithin alone and tocopheryl acetate (vitamin E). Ethanol (1.6 g/kg body wt/day for 12 weeks) exposure increased thiobarbituric acid reactive substance (TBARS) level, while decreased superoxide dismutase (SOD) activity and reduced glutathione (GSH) content in whole blood hemolysate of 8-10 week-old male BALB/c mice (weighing 20-30 g). The activities of transaminase (AST and ALT) enzymes, interleukin (IL)-10 and gamma interferon (IFN-γ) elevated, while IL-2 and IL-4 reduced in mice serum due to ethanol exposure. These suggested that oxidative stress and immunomodulatory activities were interdependent and associated with ethanol induced liver damage. Lecithin treatment significantly reduced AST (32.44%), ALT (32.09%), IL- 10 (25.63%) activities and TBARS content (12.76%) compared to ethanol treated group. However, lecithin with vitamin-B complex treatment, significantly reduced AST (62.83%); ALT (61.96%); IL-10 (35.88%); IFN-γ (22.55%) activities and TBARS content (31.58%), while significantly elevated GSH content (36.49%) and SOD activity (61.21%). Tocopheryl acetate treatment significantly reduced AST (62.83%); ALT (61.54%); IL-10 (36.35%); IFN-γ (23.28%) activities and TBARS content (35.84%), while significantly elevated GSH content (28.76%) and SOD activity (62.42%) compared to ethanol treated group. These findings persuasively argued that lecithin with vitamin-B complex was a new promising therapeutic approach in controlling ethanol induced immunomodulatory activities involving liver damage processes. Prevention of oxidative stress with correction of nutritional deficiency caused alteration in the ethanol-induced immunomodulatory activities and associated liver diseases .</p>

Notes:

cited By 5

Cite this Research Publication

D. M. Vasudevan, Das, S. K., Gupta, G., and Rao, D. N., “Effect of lecithin with vitamin-b complex and tocopheryl acetate on long term effect of ethanol induced immunomodulatory activities”, Indian Journal of Experimental Biology, vol. 45, pp. 683-688, 2007.

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