Publication Type:

Journal Article


Indian Journal of Clinical Biochemistry, Springer, Volume 24, Issue 3, Number 3, p.301–306 (2009)



Ethanol Glutathione Liver function Nitric oxide Oxidative stress Transforming growth factor Vascular endothelial growth factor


Alcohol consumption and health outcomes are complex and multidimensional. Ethanol (1.6g / kg body weight/ day) exposure initially affects liver function followed by renal function of 16–18 week-old male albino rats of Wistar strain weighing 200–220 g. Chronic ethanol ingestion increased in thiobarbituric acid reactive substances level and glutathione s-transferase activity; while decreased reduced gluatathione content and activities of catalase, glutathione peroxidase and glutathione reductase in a time dependent manner in the hemolysate. Though superoxide dismutase activity increased initially might be due to adaptive response, but decreased later. Elevation of serum nitrite level and transforming growth factor-b1 activity indicated that long-term ethanol consumption may cause hepatic fibrosis and can elicit pro-angiogenic factors. However, no alteration in vascular endothelial growth factor-C activity indicated that ethanol consumption is not associated with lymphangiogenesis. Therefore, we conclude that long-term ethanol-induced toxicity is linked to an oxidative stress, which may aggravate to fibrosis and elevate pro-angiogenic factors, but not associated with lymphangiogenesis.


cited By 11

Cite this Research Publication

S. Kumar Das, Dhanya, L., Varadhan, S., Mukherjee, S., and Vasudevan, D. M., “Effects of chronic ethanol consumption in blood: a time dependent study on rat”, Indian Journal of Clinical Biochemistry, vol. 24, no. 3, pp. 301–306, 2009.