Publication Type:

Journal Article

Source:

Indian Journal of Clinical Biochemistry, Volume 23, Number 4, p.341-344 (2008)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-57149088496&partnerID=40&md5=6171ad96af9c7e92a047dd94963a63a2

Keywords:

alcohol, alcohol consumption, animal experiment, animal tissue, article, calcium, calcium blood level, catalase, controlled study, creatinine, creatinine blood level, enzyme activity, glutathione peroxidase, glutathione reductase, glutathione transferase, kidney function, kidney function test, kidney malformation, kidney mass, kidney structure, long term exposure, male, nephrotoxicity, nonhuman, oxidative stress, rat, superoxide dismutase, thiobarbituric acid reactive substance, ultrastructure, urea, urea blood level

Abstract:

After administration, ethanol and its metabolites go through the kidneys and are excreted into urine. The kidney seems to be the only vital organ generally spared in chronic alcoholics. Therefore, we investigated the multiple effects of chronic ethanol exposure on renal function tests and on oxidative stress related parameters in the kidney. Chronic ethanol (1.6 g ethanol/ kg body weight/ day) exposure did not show any significant change in relative weight (g/ 100g body weight) of kidneys, serum calcium level or glutathione s-transferase activity. However, urea and creatinine concentration in serum, and TBARS level in kidney elevated significantly, while reduced glutathione content and activities of glutathione peroxidase, glutathione reductase and superoxide dismutase diminished significantly after 12 weeks of ethanol exposure. Catalase activity showed increased activity after 4 weeks of ethanol exposure and decreased activity after 12 weeks of ethanol exposure. Genesis of renal ultrastructural abnormalities after 12 weeks of ethanol exposure may be important for the development of functional disturbances. This study revealed that chronic ethanol exposure for longer duration is associated with deleterious effects in the kidney.

Notes:

cited By 8

Cite this Research Publication

S. K. Das, Varadhan, S., Dhanya, L., Mukherjee, S., and Vasudevan, D. M., “Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney”, Indian Journal of Clinical Biochemistry, vol. 23, pp. 341-344, 2008.