Publication Type:

Journal Article


Indian Journal of Clinical Biochemistry, Volume 26, Number 1, p.84-87 (2011)



alcohol consumption, alcohol liver cirrhosis, animal experiment, animal model, animal tissue, apoptosis, article, caspase 3, caspase 8, controlled study, enzyme activity, male, nick end labeling, nonhuman, rat


Apoptosis plays an important role in cellular homeostasis. In this study we have investigated whether apoptosis is a contributory factor to alcohol induced liver damage. Long term ethanol (1.6 g/kg body weight/day) exposure augmented liver apoptosis as reflected by high frequency of positive TUNEL staining nuclei and by an increased activity of caspase-3 and -8. Our study provides evidence that long-term ethanol consumption triggers apoptotic process in the liver. © 2010 Association of Clinical Biochemists of India.


cited By 3

Cite this Research Publication

D. M. Vasudevan, Das, S. K., and Mukherjee, S., “Effects of long term ethanol consumption on cell death in liver”, Indian Journal of Clinical Biochemistry, vol. 26, pp. 84-87, 2011.