Apoptosis plays an important role in cellular homeostasis. In this study we have investigated whether apoptosis is a contributory factor to alcohol induced liver damage. Long term ethanol (1.6 g/kg body weight/day) exposure augmented liver apoptosis as reflected by high frequency of positive TUNEL staining nuclei and by an increased activity of caspase-3 and -8. Our study provides evidence that long-term ethanol consumption triggers apoptotic process in the liver. © 2010 Association of Clinical Biochemists of India.
cited By 3
D. M. Vasudevan, Das, S. K., and Mukherjee, S., “Effects of long term ethanol consumption on cell death in liver”, Indian Journal of Clinical Biochemistry, vol. 26, pp. 84-87, 2011.