Publication Type:

Journal Article


Toxicology Mechanisms and Methods, Volume 22, Number 5, p.375-382 (2012)



alcohol consumption, Alcoholic, angiogenesis, animal experiment, animal tissue, Animals, article, catalase, Cell Hypoxia, controlled study, cytokine production, Cytokines, enzyme activation, enzyme activity, Ethanol, Fibrosis, glutathione, glutathione peroxidase, glutathione reductase, glutathione transferase, histopathology, immunohistochemistry, interleukin 1, interleukin 10, liver, Liver Diseases, liver fibrosis, Liver Function Tests, liver regeneration, male, matrix metalloproteinase, Matrix Metalloproteinases, Neovascularization, nonhuman, oxidative stress, Pathologic, priority journal, protein expression, rat, Rats, Rattus, superoxide dismutase, thiobarbituric acid reactive substance, Time Factors, transforming growth factor beta1, tumor necrosis factor alpha, Vascular Endothelial Growth Factor Receptor-2, vasculotropin receptor 2, von Willebrand factor, Wistar


Angiogenesis, the growth of new blood vessels, is essential during tissue repair. Though most molecular mechanisms of angiogenesis are common to the liver and other organs, there was no report available whether alcoholic liver disease also causes angiogenesis. In this study, we examined the effects of long term ethanol (1.6g/kg body weight/day) consumption on angiogenic responses in the liver of male Wistar strain albino rats (1618 weeks old, weighing 200220g) up to 36 weeks. Chronic ethanol consumption was associated with not only elevated oxidative stress, and altered cytokines expression, but also developed large von Willebrand factor, fibrosis and activation of matrix metalloproteinases. Moreover, vascular endothelial growth factor-receptor 2 (VEGF-R2, fetal liver kinase 1: Flk-1/KDR) expression and neovessel generation in the rat liver were noted after 36 weeks of ethanol consumption. Thus our study provides novel evidence that long-term ethanol consumption is associated with angiogenesis through delicate and coordinated action of a variety of mediators. © 2012 Informa Healthcare USA, Inc.


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Cite this Research Publication

, Mukherjee, S., and Vasudevan, D. M., “Effects of long term ethanol consumption mediated oxidative stress on neovessel generation in liver”, Toxicology Mechanisms and Methods, vol. 22, pp. 375-382, 2012.