Publication Type:

Journal Article

Source:

Research Journal of Pharmaceutical Dosage Forms and Technology, A & V Publications, Volume 4, Number 6, p.318–319 (2012)

URL:

http://www.indianjournals.com/ijor.aspx?target=ijor:rjpdft&volume=4&issue=6&article=004#top

Keywords:

anti-inflammatory, NSAID., Propionitrile, Sodamide, Tiaprofenic acid

Abstract:

An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Cite this Research Publication

K. Raghubabu, Dr. Madhu Mohan N., Kalyanaramu, B., Ramadas, C., and Narayanarao, M., “Efficient and viable synthesis development for Tiaprofenic Acid in pharmaceutical industries”, Research Journal of Pharmaceutical Dosage Forms and Technology, vol. 4, pp. 318–319, 2012.

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