Efficient syntheses of (±) [2-2H2]mevalonolactone and (±) [2-2H2]homomevalonolactone involving condensations of lithiotrimethylsilyl [2-2 H2]acetate with appropriate 3-oxo-alcohols are described. Regiospecificity of the label was established by NMR spectroscopy.
A. Banerji and Kalena, G. P., “Efficient syntheses of ($\pm$)[2-2H2] mevalonolactone and ($\pm$)[2-2H2] homomevalonolactone”, Journal of Labelled Compounds and Radiopharmaceuticals, vol. 25, pp. 111–115, 1988.