Publication Type:

Journal Article


Carbohydrate Polymers, Volume 83, Number 2, p.452-461 (2011)



AFM, Biochemistry, Biological properties, Biomedical applications, Cancer cells, Carboxymethyl chitosan, Cellular uptake, Chemotherapeutic agents, chitin, chitosan, curcumin, cytotoxicity, Drug delivery, Drug delivery applications, fluorescence microscopy, In-vitro, Mean diameter, MTT assays, Nanocarriers, Nanoformulation, Nanoparticles, O-carboxymethyl chitosans, Particle size analysis, SEM, Size analysis, Spherical particle, Toxic materials, Watersoluble, XRD


Carboxymethyl chitosan derivatives are widely used for biomedical applications because of their non-toxic and biodegradable properties. Curcumin is a phytochemical with immense biological properties. But its hydrophobicity and poor oral bioavailability limits its application as a chemotherapeutic agent. To increase the oral bioavailability, we developed curcumin loaded O-CMC nanoparticles (curcumin-O-CMC Nps). The prepared nanoparticles were characterized by DLS, AFM, SEM, FT-IR, XRD and TG/DTA. Size analysis studies revealed spherical particles with mean diameter of about 150 ± 30 nm. Curcumin was entrapped in O-CMC with an efficiency of 87%. In vitro drug release profile was studied at 37 °C under different pHs (7.4 and 4.5) with and without lysozyme. Cytotoxicity studies by MTT assay indicated that curcumin-O-CMC Nps were toxic to cancer and non-toxic to normal cells. Cellular uptake of the curcumin-O-CMC Nps was analyzed by fluorescence microscopy and FACS. Overall these studies indicated O-CMC as a promising nanomatrix for drug delivery applications. © 2010 Elsevier Ltd. All rights reserved.


cited By 75

Cite this Research Publication

A. Anitha, Maya, S., Deepa, N., Chennazhi, K. P., Nair, S. V., Tamura, H., and Jayakumar, R., “Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells”, Carbohydrate Polymers, vol. 83, pp. 452-461, 2011.