In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. The myeloperoxidase (MPO) enzyme activity in WBC was quantitated. The three patients snowed a significant increase in the MPO activity when compared with two untreated controls indicating the efficacy of GM-CSF as a protective agent. It is suggested that further detailed studies with larger number of patients would be useful.
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N. Ananth, ,, Dr. Damodaran Vasudevan, Souza, V. D., Rao, A. V., and Nambiar, D., “Enhancement of myeloperoxidase activity in wbcs in oral cancer patients treated with granulocyte macrophage colony stimulating factor (GM-CSF) - A pilot study”, Indian Journal of Clinical Biochemistry, vol. 13, pp. 126-128, 1998.