Publication Type:

Journal Article


Life Sciences, Volume 81, Number 23-24, p.1555-1564 (2007)



angiogenesis, angiopoietin, angiostatin, Animals, Blood Platelets, endostatin, energy metabolism, fibroblast growth factor, human, Humans, hypoxia, Immune system, integrin, Intercellular Signaling Peptides and Proteins, liver, Liver Circulation, matrix metalloproteinase, Neovascularization, neuropilin, nitric oxide, osteonectin, Physiologic, Protein interaction, review, signal transduction, thrombocyte, thrombocyte factor, thrombospondin, tissue repair, transforming growth factor beta


<p>Angiogenesis, the growth of new blood vessels, is essential during tissue repair. In contrast, uncontrolled angiogenesis promotes tumor. A balance between proangiogenic and antiangiogenic growth factors and cytokines tightly controls angiogenesis. With the identification of several proangiogenic molecules such as the vascular endothelial cell growth factor (VEGF), the fibroblast growth factors (FGFs), and the angiopoietins, and the recent description of specific inhibitors of angiogenesis such as platelet factor, angiostatin, endostatin, and vasostatin, it is recognized that therapeutic interference with vasculature formation offers a tool for clinical applications in various pathologies. © 2007 Elsevier Inc. All rights reserved.</p>


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Cite this Research Publication

S. K. Das and Vasudevan, D. M., “Essential factors associated with hepatic angiogenesis”, Life Sciences, vol. 81, pp. 1555-1564, 2007.