Ethosomes for transdermal and topical drug delivery
Publication Type:Journal Article
Source:International Journal of Pharmacy and Pharmaceutical Sciences, Volume 4, Number SUPPL.3, p.17-24 (2012)
Keywords:2 propanol, alcohol, alkaloid, ammonium glycyrrhizate, aqueous solution, bacterial infection, cell membrane, chemical analysis, chemical composition, colloid, confocal laser microscopy, dendritic cell vaccine, diabetes mellitus, diethylene glycol monoethyl ether, differential scanning calorimetry, dispersion, drug absorption, drug bioavailability, drug blood level, drug delivery system, drug design, drug efficacy, drug formulation, drug half life, drug metabolism, drug penetration, drug solubility, drug stability, Dynamic light scattering, erythromycin, ethosome, flow cytometry, fluorescence microscopy, gel permeation chromatography, glycol, glycyrrhetinic acid derivative, green fluorescent protein, heating, hepatitis B, hepatitis B vaccine, hormone, human, hydrophilicity, immunization, in vitro gene transfer, in vivo study, indinavir, insulin, lemannine, light scattering, lipid, lipid vesicle, lipoduction, lipophilicity, liposomal delivery, methotrexate, minoxidil, naloxone, nanominox, noicellex, nonhuman, Parkinson disease, particle size, phosphatidylcholine, phosphatidylethanolamine, phospholipid, phosphorus nuclear magnetic resonance, physical chemistry, propylene glycol, quantum dot, review, salbutamol sulfate, scanning electron microscopy, skin penetration, sophocarpine, Staphylococcus infection, suspension, testosderm patch, testosome, testosterone, transcutaneous immunization, transmission electron microscopy, trihexyphenidyl, ultracentrifugation, unclassified drug, unindexed drug, zeta potential
Ethosomes are elastic lipid vesicular drug delivery systems embodying relatively high concentration of alcohol. These "soft vesicles" are very efficient at transporting active substances through the stratum corneum into the deeper layers of the skin than conventional liposomes. A proposed mechanism of the percutaneous permeation enhancing effect of ethosomal system is the dual fluidizing effect of alcohol on the ethosomal lipid layers and on the stratum corneum lipids. Ethosomes can act as a carrier for large and diverse group of drugs with different physicochemical properties and found a number of applications in pharmaceutical, biotechnological and cosmetic fields. This article highlights the current status of the development of ethosome and summarizes its advantages, composition, methods of preparation, mechanism of skin penetration, characterization, applications and stability.
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