Ethosomes are elastic lipid vesicular drug delivery systems embodying relatively high concentration of alcohol. These "soft vesicles" are very efficient at transporting active substances through the stratum corneum into the deeper layers of the skin than conventional liposomes. A proposed mechanism of the percutaneous permeation enhancing effect of ethosomal system is the dual fluidizing effect of alcohol on the ethosomal lipid layers and on the stratum corneum lipids. Ethosomes can act as a carrier for large and diverse group of drugs with different physicochemical properties and found a number of applications in pharmaceutical, biotechnological and cosmetic fields. This article highlights the current status of the development of ethosome and summarizes its advantages, composition, methods of preparation, mechanism of skin penetration, characterization, applications and stability.
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R. Rakesh and Anoop, K. R., “Ethosomes for transdermal and topical drug delivery”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 4, pp. 17-24, 2012.