An oligoquinoxaline derivative with phthalazine core has been prepared by condensation of 1,4-dihydrazinophthalazine with 2,3-dichloroquinoxaline in dry ethanol followed by acid hydrolysis. Classical endogenous bridging of phthalazine core with its diazine fragment was established in the transition metal(II) complexes derived from the ligand system by using various physicochemical and spectral techniques. The organic host acts as a hexadentate chelate with N4O2 donating sites for coordination towards later first-row transition metal ions. Complexes are in good agreement with the octahedral geometry and found to be 1:1 electrolytes. All synthesized compounds were screened for anticonvulsant activity in Wistar rats by using maximal electroshock method. The ligand, and Co(II) and Ni(II) complexes show appreciable suppression towards electroshock-induced seizures.
Srinivasa Budagumpi, Dr. Naveen V. Kulkarni, M. P. Sathisha, Sandeep P. Netalkar, Vidyanand K. Revankar, and D. K. Suresh, “Exploration on structure and anticonvulsant activity of transition metal complexes derived from an ``end-off'' compartmental bis-quinoxaline derivative with phthalazinyl-diazine as endogenous bridge”, Monatshefte für Chemie - Chemical Monthly, vol. 142, p. 487, 2011.