Being able to counter immune-mediated rejection has for decades been the single largest obstacle for the progress of vascular composite allotransplantation (VCA). The human immune system performs the key role of differentiating the 'self ' from the 'non-self '. This, although is quintessential to eliminate or resist infections, also resists the acceptance of an allograft which it promptly recognises as 'non-self'.
Dr. Lalitha Biswas, S, I., M, S., P, K., J, M., R, J., R, R., A, W., ,, SM, C. Mali, V, V., A, C., S, D., A, O., G, K., R, N., A, M., Z, P., and M, E., “First Two Bilateral Hand Transplantations in India (Part 4): Immediate Post-operative Care, Immunosuppression Protocol and Monitoring”, Indian J Plast Surg, vol. 50, no. 2, pp. 168-172, 2017.