Publication Type:

Journal Article

Source:

Chemical Communications, The Royal Society of Chemistry, Volume 49, p.7141-7143 (2013)

URL:

http://dx.doi.org/10.1039/C3CC42653J

Abstract:

We present the design{,} synthesis{,} optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer{,} a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.

Cite this Research Publication

S. Bhuniya, Lee, M. Hee, Jeon, H. Mi, Han, J. Hye, Lee, J. Hong, Park, N., Maiti, S., Kang, C., and Kim, J. Seung, “A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells”, Chemical Communications, vol. 49, pp. 7141-7143, 2013.