Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 1:1:1, 1:1:3, and 1:1:6. The flow property of granules was found to be good for the formulation CZ2 (1:1:3). The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 (1:1:3).The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 (1:1:3).
S. Subramanian, Sankar, V., Asha Asokan Manakadan, Ismail, S., and Andhuvan, G., “Formulation and evaluation of Cetirizine dihydrochloride orodispersible tablet”, Pakistan Journal of Pharmaceutical Sciences, vol. 23, no. 2, pp. 232-235, 2010.