Publication Type:

Journal Article

Source:

Asian Journal of Pharmaceutical and Clinical Research, Innovare Academics Sciences Pvt. Ltd, Volume 10, Number 2, p.319-324 (2017)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012008689&doi=10.22159%2fajpcr.2017.v10i2.15696&partnerID=40&md5=e089628ee6f2be78014ae97945050a63

Abstract:

<p>Objective: To formulate and evaluate an extended-release (ER) tablet of a new molecule, 2-amino-4-(4-bromophenyl)-7-hydroxy-4H-chromene-3-carbonitrile using a combination of two polymers (hydroxypropyl methyl cellulose [HPMC] K100 and HPMC phthalate) which control the rate and degree of the drug release through 12 hrs period and protect the drug release from acidic pH. Methods: Five batches of tablets (4HC1, 4HC2, 4HC3, 4HC4, 4HC5) were produced by direct compression method. Morphological evaluation of the powder blend was carried out by differential scanning calorimetry and Powered X-ray diffractometry. The evaluation studies such as flow properties, hardness, friability, drug content, and release study were conducted according to pharmacopoeial standards. Results: The physicochemical characteristics of all the granules and tablets were generally satisfactory. The drug release followed zero order, Higuchi model kinetics with diffusion and dissolution mediated mechanism. Tablets were evaluated for physicochemical parameters and promising. Stability studies indicated the dosage form is stable for 3 months at accelerated conditions. Conclusion: From the results received from all test, it was concluded that formulation 4HC4 are the most suitable choice for developing 12 hrs ER tablets. This finding reveals that a particular concentration of HPMC K100 was capable of producing ER. © 2017 The Authors.</p>

Notes:

cited By 0

Cite this Research Publication

K. Pa Reshmi, Dr. Subin Mary Zachariah, and Dr. Vidya Viswanad, “Formulation and evaluation of novel chromene derivative as an anti-inflammatory agent used for inflammatory bowel diseases”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 319-324, 2017.

207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS