Publication Type:

Journal Article


FEBS Letters, Volume 584, Number 3, p.531-536 (2010)



3T3-L1 Cells, Androstadienes, animal cell, animal cell culture, Animals, article, Biological Transport, cell strain 3T3, controlled study, drug activity, drug isolation, drug purification, gallic acid, genetic transfection, Glucose, glucose transport, glucose transporter 4, Glucose Transporter Type 4, Hippophae rhamnoides, Hippophae rhamnoides extract, Mice, nonhuman, plant leaf, priority journal, proadipocyte, protein kinase B, protein kinase C lambda, protein kinase C zeta, Protein Kinase Inhibitors, protein transport, Western blotting, wortmannin


<p>GLUT4, a 12 transmembrane protein, plays a major role in insulin mediated glucose transport in muscle and adipocytes. For glucose transport, the GLUT4 protein needs to be translocated to the plasma membrane from the intracellular pool and it is possible that certain compounds may be able to enhance this process. In the present work, we have shown that gallic acid can increase GLUT4 translocation and glucose uptake activity in an Akt-independent but wortmannin-sensitive manner. Further analysis suggested the role of atypical protein kinase Cζ/λ in gallic acid mediated GLUT4 translocation and glucose uptake. © 2009 Federation of European Biochemical Societies.</p>


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Cite this Research Publication

C. N. Vishnu Prasad, Anjana, T., Banerji, A., and Gopalakrishnapillai, A., “Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells”, FEBS Letters, vol. 584, pp. 531-536, 2010.