Gold nanoparticles (Au-NPs) based chitin-MnO2 ternary composite nanogels (ACM-TNGs) were prepared by the regeneration of chitin along with MnO2 nanorods (5-20 nm) and the incorporation of 10 nm sized Au-NPs to make "ACM-TNGs". They were characterized with FT-IR, TG, and UV spectroscopy. The SEM showed spindle shaped 200 nm sized chitin-MnO2 nanogels (chitin-MnO2 NGs), whereas ACM-TNGs had spindle sizes of 220 nm. The ACM-TNGs were compatible up to 1 mg mL-1 and showed uptake into L929, HDF, MG63, T47D and A375 cell lines without affecting the cellular morphology. ACM-TNGs showed conductivity, and heating under a radio frequency (RF) source at 100 W for 2 min. They also showed the ability to kill breast cancer cells under RF radiation at 100 W for 2 min, when compared with the chitin-MnO2 NGs. The RF assisted ablation of breast cancer cells was confirmed by a live/dead assay. These results suggests that ACM-TNGs could be useful for the RF assisted cancer cells ablation with minimal toxicity compared with MnO2 nanorods.
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N. S. Rejinold, Ranjusha, R., Balakrishnan, A., Mohammed, N., and Dr. Jayakumar Rangasamy, “Gold-chitin-manganese Dioxide Ternary Composite Nanogels for Radio Frequency Assisted Cancer Therapy”, RSC Advances, vol. 4, pp. 5819-5825, 2014.