Publication Type:

Journal Article


RSC Advances, Royal Society of Chemistry, Volume 6, Number 67, p.62385-62389 (2016)



Anti-proliferative activities, Anticancer drug, biocompatibility, Biocompatible polymer, Body fluids, Camptothecin (CPT), Cancerous cells, Fluorescence intensities, Grafting (chemical), Graphene, Graphene oxides, Polyvinyl alcohols, Targeted delivery


A water-soluble and biocompatible polymer, i.e. biotinylated poly(vinyl alcohol)-grafted graphene oxide (GO), was used as a nanocarrier for targeted delivery of anticancer drug camptothecin (CPT). The extent of CPT release in the presence of glutathione (GSH) from GO-biotinPVA-CPT was monitored by the increase in the fluorescence intensity, at λmax = 450 nm. The cell-specific (HeLa) antiproliferative activity of GO-biotinPVA-CPT makes it suitable to be used for targeted delivery of chemotherapeutics to cancerous cells.


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Cite this Research Publication

K. Y. Yasoda, Bobba, K. N., Nedungadi, D., Dutta, D., Kumar, M. S., Kothurkar, Nd, Mishra, N., and Bhuniya, S., “GSH-responsive biotinylated poly(vinyl alcohol)-grafted GO as a nanocarrier for targeted delivery of camptothecin”, RSC Advances, vol. 6, pp. 62385-62389, 2016.