Publication Type:

Journal Article

Source:

Journal of the Indian Medical Association, Volume 107, Number 2, p.72-77 (2009)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-68949118396&partnerID=40&md5=569a5f9ab2d2078937d8416d72f993b2

Keywords:

adult, article, autoimmunity, cluster analysis, cohort analysis, Cohort Studies, cross-sectional study, female, free thyroxine index, Goiter, health survey, Health Surveys, human, Humans, hyperthyroidism, hypothyroidism, immunology, India, iodine, major clinical study, male, middle aged, population research, prevalence, sex difference, Socioeconomic Factors, socioeconomics, thyroid disease, Thyroid Diseases, thyroid function test, thyroid peroxidase antibody, thyrotropin, thyrotropin blood level, thyroxine blood level, urban population, urinary excretion, Urine

Abstract:

India is in the transition phase from iodine deficiency to iodine sufficiency, and this is expected to change the thyroid status of the population. The thyroid status and auto-immune status of adult Indian population in the postlodisation phase is largely unknown, and this study was conducted to answer this question. A cross-sectional population survey was conducted in two phases among the residents of urban coastal area of central Kerala. The initial phase included a house-to-house survey of 3069 adults (>18 years of age), selected by cluster sampling method. From the surveyed population, 986 subjects underwent further physical examination and biochemical evaluation for thyroid function, thyroid auto-immunity status and iodine status. The total prevalence of goitre was 12.2% and median urine iodine excretion was 211.4 mcg/l (mean 220.3±99.5 mcg/l) indicating iodine sufficiency. Thyroid function abnormalities were present in 19.6% of subjects. Subclinical hypothyroidism was present in 9.4%. Among the population with normal thyroid function, 9.5% and 8.5% respectively had positive anti-TPO and anti-TG antibodies. Among those with thyroid dysfunction, 46.3% had positive antiTPO and 26.8% were antiTG positive. A significant proportion of this iodine-sufficient adult population had thyroid disorders. Further studies are required to characterise the reasons for this high prevalence. Iodine deficiency as well as thyroid dysfunction should both be the focus of public health strategies in susceptible populations.

Notes:

cited By (since 1996)11

Cite this Research Publication

V. Ua Menon, Sundaram, K. Rab, Unnikrishnan, A. Ga, Jayakumar, R. Va, Nair, Va, and Kumar, Ha, “High prevalence of undetected thyroid disorders in an iodine sufficient adult south Indian population”, Journal of the Indian Medical Association, vol. 107, pp. 72-77, 2009.