A new member of the angucycline family, vineomycin C (3), together with four known metabolites saquayamycin A1 (1), A-7884 (2), rabelomycin (5) and xanthomegnin (6) were isolated from microbial extracts. The structures were determined by 1D and 2D NMR techniques and chemical degradation. Compounds 1-3 and 5 were isolated from a fermentation of Streptomyces sp., while 6 was isolated from a fungal fermentation extract. All five compounds have shown potent inhibitory activity in the inducible nitric oxide synthase (iNOS) assay.
Dr. Bipin G. Nair, K. A. Alvi, D. B. Baker, V. Steinecker, and M. Hosken, “Identification of Inhibitors of Inducible Nitric Oxide Synthase from Microbial Extracts”, J. Antibiotics, vol. 53, pp. 496-501, 2000.